Otto III, born seven years after the death of his grandfather, would grow up nourished on dreams of empire. In large part, this was due to the influence of Adelaide and Theophano, who raised him on tales of Byzantine glory. Indeed, the role of women was a consistent and powerful theme in the story of the medieval Holy Roman emperors, who were strongly impacted by their mothers and wives. After the death of Otto II in 983, Theophano and Adelaide ruled the empire as regents until Otto came of age at fourteen.
Like his grandfather, Otto spent much of his career in Rome, where in 996 his cousin Pope Gregory V crowned him emperor. Two years later, Gregory died, and Otto made his friend Gerbert pope as Sylvester II. Otto the Great had established the tradition of Holy Roman emperors choosing popes when, a year after his coronation, he had removed the corrupt John XII from his papal seat. In so doing, the grandfather had established a source of later conflict with the popes.
The fact that Otto III spent most of his reign in Rome rather than in Germany indicates his grand designs of a restored Roman Empire. So, too, does the motto on his seal ring, which he used to inscribe official documents: "The Renewal of the Roman Empire." He sent a crown to the Byzantine emperor Basil II (see entry), proclaiming him ruler of the East as Otto was ruler of the West. Basil had no interest in forming such an alliance, but he did offer his niece in marriage to Otto. Twenty-two-year-old Otto, however, did not live long enough to marry.