Although there is no evidence that Circe is based on a real historical figure, medical experts have speculated about a possible scientific explanation for her potions and Odysseus's antidote. This assumes the effect of Circe's potion is not taken literally—in other words, victims are not actually transformed into animals.
A potion that causes hallucinations, memory loss, and confusion could be made from a group of naturally occurring substances known as anticholinergics. These substances are found in deadly nightshade and other plants found in the region associated with the Circe myth. Such a potion could result in a victim feeling as if he or she were under a magical spell. (It is important to note that deadly nightshade is one of the most poisonous plants known to humans and should never be consumed or fed to anyone.)
In addition, the plant that Homer describes as protection against Circe's potion—referred to as “moly”—matches descriptions of a plant known today as the snowdrop. The snowdrop contains a natural substance that can reduce the effects of anticholinergics, thus offering protection from such a potion.
She controls wild beasts such as lions and wolves, and has a deep connection with the ancient, dark forces of nature. This dark, mysterious connection with nature is something that was, long before the ancient Greeks, associated with women. Odysseus, a clever man, recognizes and respects Circe’s power. It is only with divine help that he outmaneuvers her. The story of Circe seems to be a warning to Greek men that if they did not firmly control women, women would control them.
Circe has much in common with later conceptions of witches in Europe and North America. She knows how to use herbs to create spells and potions, which she whips up in a bubbling cauldron. She even has a stick or staff, much like a witch’s wand.